منابع مشابه
Combination of Modafinil and d-amphetamine for the Treatment of Cocaine Dependence: A Preliminary Investigation
BACKGROUND Two stimulant medications, modafinil and d-amphetamine, when tested individually, have shown safety and efficacy for treatment of cocaine addiction. We hypothesized that the combination of modafinil and d-amphetamine, at low doses, would show equivalent or greater benefit in reducing cocaine use compared to higher doses of each individual medication or placebo. METHODS Sixteen week...
متن کاملA Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence
U SE OF cocaine continues to be a serious problem in the United States. The 1998 National Household Survey on Drug Abuse reported 1.8 million current users, with a significant increase in use among those aged 18 to 25 years relative to the previous year. At present, there are few conventional treatments with demonstrated efficacy available for the treatment of this disorder. Given the lack of c...
متن کاملA Randomized Controlled Trial of Auricular Acupuncture for Cocaine Dependence
U SE OF cocaine continues to be a serious problem in the United States. The 1998 National Household Survey on Drug Abuse reported 1.8 million current users, with a significant increase in use among those aged 18 to 25 years relative to the previous year. At present, there are few conventional treatments with demonstrated efficacy available for the treatment of this disorder. Given the lack of c...
متن کاملDiscriminative-stimulus effects of modafinil in cocaine-trained humans.
Modafinil is a novel stimulant that is effective in the treatment of narcolepsy and excessive daytime sleepiness. In vitro and in vivo neuropharmacological data suggest that the mechanism of action of modafinil is distinct from that of prototypical abused stimulants like cocaine and d-amphetamine. In the present experiment, six human volunteers with recent histories of cocaine use learned to di...
متن کاملNeurophysiological effects of modafinil on cue-exposure in cocaine dependence: a randomized placebo-controlled cross-over study using pharmacological fMRI.
OBJECTIVE Enhanced reactivity to substance related cues is a central characteristic of addiction and has been associated with increased activity in motivation, attention, and memory related brain circuits and with a higher probability of relapse. Modafinil was promising in the first clinical trials in cocaine dependence, and was able to reduce craving in addictive disorders. However, its mechan...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2005
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1300866